论文部分内容阅读
目的观察甘精胰岛素联合阿卡波糖治疗老年2型糖尿病的疗效及安全性。方法将50例老年2型糖尿病患者随机分为观察组和对照组各25例。观察组甘精胰岛素联合阿卡波糖治疗;对照组给予预混人胰岛素治疗,观察期为3个月。观察2组患者治疗前后空腹血糖(FPG)、餐后2h血糖(2h PG)、糖化血红蛋白(Hb A1c)水平及低血糖发生的情况。结果治疗后2组患者的FPG、2h PG、Hb A1c均低于治疗前,差异均有统计学意义(P<0.05),但上述指标组间比较差异无统计学意义(P>0.05)。治疗期间观察组低血糖发生率为4.0%(1/25)低于对照组的24.0%(6/25),差异有统计学意义(P<0.05)。结论甘精胰岛素联合阿卡波糖可有效控制血糖,同时降低低血糖发生率,值得在临床推广。
Objective To observe the efficacy and safety of insulin glargine combined with acarbose in the treatment of type 2 diabetes in the elderly. Methods 50 elderly patients with type 2 diabetes mellitus were randomly divided into observation group and control group, 25 cases each. Observation group glargine combined with acarbose treatment; control group was given pre-mixed insulin treatment, the observation period of 3 months. The levels of fasting blood glucose (FPG), 2h postprandial glucose (2h PG), Hb A1c and the incidence of hypoglycemia in both groups before and after treatment were observed. Results The FPG, 2h PG and Hb A1c in two groups after treatment were significantly lower than those before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). During the treatment period, the incidence of hypoglycemia in the observation group was 4.0% (1/25), which was lower than that in the control group (24.0%, 6/25). The difference was statistically significant (P <0.05). Conclusion Glargine combined with acarbose can effectively control blood glucose, while reducing the incidence of hypoglycemia, it is worth in the clinical promotion.