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基于电化学检测法具有无需衍生、高灵敏度、高选择性以及成本低的特点,高效液相色谱-电化学检测法(HPLC-ED)已经成为药物分析的重要工具。从HPLC-ED技术开始使用40年以来,已有大量相关文章和综述发表。本文将对应用在HPLC中的电化学检测器和检测方法进行回顾,重点介绍HPLC-ED技术在药物分析中的最新研究进展,并讨论这种技术的未来发展趋势。
Based on the advantages of no derivatization, high sensitivity, high selectivity and low cost, HPLC-ED has become an important tool for drug analysis. A large number of articles and reviews have been published since the beginning of HPLC-ED technology for 40 years. This article reviews the electrochemical detectors and detection methods used in HPLC, highlighting the latest research advances in HPLC-ED technology and discussing the future development trend of this technology.