由于抗肿瘤药物服药后缺乏肿瘤特异性,而且毒性很大,因而近十年来为寻找选择性的定位抗肿瘤药物的途径展开大量的研究。本文报道能使药物浓集于肿瘤部位,因而毒性减小和疗效增加的二种主要方法。提高抗肿瘤药物治疗指数最有希望的方法是将药物置于高分子载体中,此载体在理论上能高度专一地定位于肿瘤部位。从而增加药物的治疗指数。最近在药物定位中已探讨出二种高分子载体,即脂质体和磁性白蛋白微球。脂质体(Liposomes) 干燥的磷脂用水溶液水化后即自然形成脂 Due to the lack of tumor specificity and high toxicity after taking the antitumor drugs, a large number of studies have been conducted in the past ten years to find alternative ways to locate antitumor drugs. This article reports two main ways in which drugs can be concentrated at the tumor site, resulting in reduced toxicity and increased efficacy. The most promising way to increase the antitumor drug therapeutic index is to place the drug in a polymer carrier that theoretically targets the tumor site with a high degree of specificity. Thus increasing the therapeutic index of the drug. Recently, two kinds of polymer carriers, namely, liposomes and magnetic albumin microspheres, have been investigated in drug localization. Liposomes Dry lipids naturally form lipids when hydrated with aqueous solutions