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目的观察坎地沙坦酯辅助治疗老年高血压合并早期肾损害的疗效。方法选择2012年12月-2014年12月在医院接受治疗的老年高血压合并早期肾损害患者78例,将其随机分为观察组和对照组各39例。对照组给予氨氯地平片加以治疗,观察组在与对照组给予相同药物治疗的基础上,用坎地沙坦酯辅助治疗。结果观察组在治疗后血压平滑指数较治疗前有明显改善,且观察组效果比对照组较优,差异具有统计学意义(P<0.05)。2组治疗后MAU、β2-MG与治疗前相比均有所降低,且观察组比对照组要低,差异具有统计学意义(P<0.05)。2组治疗后Cr、BUN与治疗前并无明显变化,不良反应发生率的差异无统计学意义(P>0.05)。并且不良反应较轻微,临床上不做特殊处理。结论坎地沙坦酯辅助氨氯地平在治疗老年高血压并保护肾脏方便有显著效果,值得临床应用。
Objective To observe the efficacy of candesartan cilexetil in the treatment of elderly patients with hypertension and early renal damage. Methods Seventy-eight elderly patients with senile hypertension and early renal impairment who were treated in the hospital from December 2012 to December 2014 were randomly divided into observation group (39 cases) and control group (39 cases). The control group was treated with amlodipine. The observation group was treated with candesartan cilexetil on the basis of the same drug treatment as the control group. Results In the observation group, the blood pressure smoothing index after treatment was significantly improved compared with that before treatment, and the effect of the observation group was better than that of the control group. The difference was statistically significant (P <0.05). The MAU and β2-MG in both groups were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P <0.05). There was no significant change in Cr and BUN between the two groups before treatment, with no significant difference in the incidence of adverse reactions (P> 0.05). And mild adverse reactions, no special clinical treatment. Conclusion Candesartan cilexetil and amlodipine are effective in treating elderly hypertension and protecting the kidneys, which is worthy of clinical application.