The great Ms8.0 Wenchuan earthquake has been the most destructive earthquake since 1949 in China. The earthquake occurred no more than half a year after the establishment of the National Strong Motion Observation Network System (NSMONS) of China; what is more, the epicenter was located in the area with dense strong motion observation stations so that a large number of strong motion records of the main shock were obtained. In this paper, 501 strong motion records from 167 observation stations are utilized to establish the ground motion attenuation relations in three directions in the range of fault distance less than 600 km. The result shows the difference of seismic motion attenuation in two horizontal directions is insignificant. It is the first time that strong-motion records are used to establish the ground motion attenuation relations of the MS8.0 earthquake in China. The great Ms8.0 Wenchuan earthquake has been the most destructive earthquake since 1949 in China. The earthquake occurred no more than half a year after the establishment of the National Strong Motion Observation Network System (NSMONS) of China; what is more, the epicenter was located in the area with dense strong motion observation so so large a number of strong motion records of the main shock were obtained. In this paper, 501 strong motion records from 167 observation stations are utilized to establish the ground motion attenuation relations in three directions in the range of fault distance less than 600 km. The result shows the difference of seismic motion attenuation in two horizontal directions is insignificant. It is the first time that strong-motion records are used to establish ground motion attenuation relations of the MS8 .0 earthquake in China.