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对于7例具有严重运动障碍的帕金森病患者,在常规内科治疗基础上,给予低剂量心得安辅助治疗。 7例患者男4例,女3例;平均年龄59±3岁;平均病程14±2年,左旋多巴治疗时间12±2年。左旋多巴每日剂量(加用外周脱羧酶抑制剂)750mg±7.6mg。7例患者均出现症状波动及严重的运动障碍,投掷或舞蹈样运动障碍4例,单纯肌张力障碍1例,以肌张力障碍为主的运动障碍2例。心得安口服30mg。加用心得安前后监测动脉血压、心率。 经用心得安治疗,患者运动障碍评分平均改善
For 7 patients with Parkinson’s disease with severe dyskinesia, low-dose propranolol was given on a routine medical basis. 7 patients were 4 males and 3 females; the average age was 59 ± 3 years; the average duration was 14 ± 2 years; levodopa treatment time was 12 ± 2 years. Levodopa daily dose (plus peripheral decarboxylase inhibitor) 750mg ± 7.6mg. Seven patients had symptoms of fluctuating and severe dyskinesia, throwing or dance-like movement disorder in 4 cases, simple dystonia in 1 case, dystonia-based dyskinesia in 2 cases. Ann assured oral 30mg. Before and after the use of safety monitoring arterial blood pressure, heart rate. After treatment with propranolol, patients with dyskinesia improved on average