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目的:观察新西兰家兔腹腔注射卵蛋白后静脉血、支气管肺泡灌洗液嗜酸粒细胞计数的表达以及家兔症状表现。方法:实验家兔分为两组,即空白对照组和模型组。模型组家兔腹腔注射10%卵蛋白(OVA),空白对照组家兔腹腔注射等剂量生理盐水,14天后模型组用1%OVA连续雾化7天诱发其哮喘发作,空白对照组则给予生理盐水雾化吸入。结果:模型组家兔出现明显腹肌抽搐、烦躁、二便失禁等症状;模型组家兔静脉血以及支气管肺泡灌洗液中的嗜酸粒细胞计数与空白对照组相比明显升高。结论:新西兰家兔腹腔注射卵蛋白成功建立支气管哮喘模型。
OBJECTIVE: To observe the expression of eosinophil counts in bronchial alveolar lavage fluid and the symptoms of rabbits after intraperitoneal injection of ovalbumin in New Zealand rabbits. Methods: Experimental rabbits were divided into two groups, namely blank control group and model group. The rabbits in the model group were injected intraperitoneally with 10% ovalbumin (OVA). The rabbits in the blank control group were injected intraperitoneally with normal saline. After 14 days, the rabbits in the model group were continuously aerosolized for 7 days with 1% OVA to induce asthma attacks. In the blank control group, Saline spray inhalation. Results: The rabbits in the model group showed obvious signs of abdominal convulsion, irritability and fecal incontinence. The eosinophil counts in the venous blood of the model group and bronchoalveolar lavage fluid were significantly higher than those in the blank control group. Conclusion: New Zealand white rabbits were injected with ovalbumin successfully established bronchial asthma model.