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多药耐药基因ｍｄｒ 1产物Ｐ 糖蛋白 (Ｐ ｇｐ)过度表达是耐药的重要原因之一。为探讨白血病细胞耐药机制及逆转方法 ,我们建立了高三尖杉酯碱 (ＨＨＴ)耐药细胞株 ,并观察了其Ｐ ｇｐ的表达及环孢菌素Ａ (ＣｓＡ)和维拉帕米 (Ｖｅｒ)在逆转耐药中并用的效果。材料和方法1 药
Multidrug resistance gene mdr 1 product P glycoprotein (P gp) overexpression is one of the important resistance. To investigate the mechanism of drug resistance and reversal of leukemia cells, we established a HHT resistant cell line and observed the expression of P gp and the effects of cyclosporin A (CsA) and verapamil ( Ver) in reversing the combined effect of resistance. Materials and methods 1 medicine