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1975年Kohler和Milstein证明骨髓瘤细胞与免疫动物的脾细胞融合形成的杂交细胞系能分泌针对免疫抗原的抗体。这种靠抗体产生细胞(B-cell,B-细胞)与骨髓瘤细胞(myeloma cells)融合产生杂交瘤细胞
In 1975, Kohler and Milstein demonstrated that hybridoma cell lines formed by the fusion of myeloma cells with splenocytes from immunized animals can secrete antibodies against the immunogenic antigens. This fusion of antibody-producing cells (B-cells) with myeloma cells produces hybridoma cells