众所周知,细菌对青霉素类和头孢菌素类耐药的最重要的机制之一是产生β-内酰胺酶。这种酶广泛地存在于革蓝氏阳性和阴性细菌中。近年来,许多重要的病原菌中产β-内酰胺酶菌株明显增加。表1列出伦敦一家医院从门诊病人分离出的耐药金葡菌出现的频率。从中看出,分离菌株中已有80％以上 It is well-known that one of the most important mechanisms of bacterial resistance to penicillins and cephalosporins is the production of beta-lactamase. This enzyme is widespread in gram-positive and-negative bacteria. In recent years, many important pathogenic bacteria producing β-lactamase strains significantly increased. Table 1 shows the frequency of emergence of resistant S. aureus isolated from outpatients at a London hospital. It can be seen that more than 80% of isolates have been isolated