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目的 :探讨轻度肾小管间质病变的慢性肾炎患者尿表皮生长因子与中医证型的关系。方法 :用放射免疫法检测尿EGF。结果 :轻度肾小管间质病变患者尿EGF含量高于正常人组 (P <0 0 1) ;肺肾气虚和气阴两虚病人尿EGF含量明显高于正常人组及脾肾阳虚组 (P <0 0 1) ;肝肾阴虚组病人尿EGF含量高于脾肾阳虚组和正常人组 (P <0 0 5 )。结论 :同是肾小管间质病变而中医分型不同 ,其尿EGF含量也不同 ,说明了不同的中医证型具有某些不同的物质基础 ,从而提示了临床辨证论治的重要性。
Objective: To investigate the relationship between urinary epidermal growth factor and TCM syndromes in patients with chronic glomerulonephritis of mild tubulointerstitial lesions. Methods: Urinary EGF was detected by radioimmunoassay. Results: The urinary EGF levels in patients with mild tubulointerstitial lesions were significantly higher than those in normal controls (P <0.01). The urinary EGF levels in patients with lung-kidney-Qi deficiency and qi-Yin deficiency were significantly higher than those in normal and spleen- P <0.01). Urinary EGF levels in patients with liver-kidney yin deficiency were higher than those in patients with spleen-kidney yang deficiency and normal controls (P <0.05). Conclusion: The same type of tubulointerstitial lesions and different TCM, its urinary EGF content is also different, indicating that different TCM syndromes have some different material basis, thus suggesting the importance of clinical syndrome differentiation.