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目的:评价黄芪建中汤治疗小儿腹泻的临床疗效。方法:检索EMBASE、PUBMED、MEDLINE、AMED、CINAHL、Cochrane图书馆、中国知网数据库、重庆维普中文科技期刊数据库、中国生物医学文献数据库、万方数据库和中国中医药期刊文献数据库从建库至2015年2月28日黄芪建中汤治疗小儿腹泻随机对照试验研究,筛选合格研究。应用Cochrane评价员手册进行偏倚风险评价,Jadad评分法进行质量评价。应用Rev Man5.3软件进行Meta分析。结果:符合纳入标准的文献共9篇。Meta分析结果显示,黄芪建中汤治疗小儿腹泻治疗组与对照组相比,临床疗效总有效率比值比(OR)为3.77,95%可信区间(confidence interval),CI(2.50,5.69),差异有统计学意义(P<0.00001);临床疗效愈显率OR为1.97,95%CI(1.50,2.60),差异有统计学意义(P<0.00001)。结论:黄芪建中汤治疗小儿腹泻临床疗效显著,但由于本系统评价纳人研究的总体质量较低,研究的数量和样本量均较小,尚需要更多高质量、多中心、大样本、严格设计的随机对试验来进一步验证其疗效与安全性。
Objective: To evaluate the clinical efficacy of Astragalus Jianzhong decoction in treating pediatric diarrhea. METHODS: The databases of EMBASE, PUBMED, MEDLINE, AMED, CINAHL, Cochrane Library, CNKI, Chongqing VPL Chinese Science and Technology Database, Chinese Biomedical Literature Database, Wanfang Database and Chinese Medicine Journal Database were searched from the database to 2015 February 28, 2009 Astragalus Jianzhong treatment of children with diarrhea, randomized controlled trials, screening of qualified research. The Cochrane reviewers’ manual was used to assess the risk of bias and the Jadad score. Meta-analysis was performed using RevMan5.3 software. Results: A total of 9 articles met the inclusion criteria. The results of Meta analysis showed that the total effective rate (OR) of the treatment group with astragalus jianzhong decoction compared with the control group was 3.77, 95% confidence interval, CI (2.50,5.69), (P <0.00001). The effective rate of clinical curative effect was 1.97, 95% CI (1.50, 2.60), the difference was statistically significant (P <0.00001). Conclusion: Astragalus jianzhong decoction has a significant curative effect on children with diarrhea. However, due to the low overall quality of this systematic review and the small number of studies and sample sizes, more high-quality, multicenter and large samples are needed. Rigorous design of randomized trials to further validate its efficacy and safety.