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作者通过冠状动脉微米缩窄器造成11条开胸犬左旋支不同程度的狭窄。测定并比较了正常、临界狭窄和重度狭窄时创伤性和非创伤性左心室收缩功能。非创伤性心功能测定指标射血前期 在心室射血时间(PEP/LVET)在临界和重度狭窄时升高5％(P<0.05)和17％(P<0.01)。而创伤性测定指标冠脉血流量(CBF)降低26％(P<0.01)和62％(P<0.01),左心室收缩压(LVSP)下降6％(P<0.05)和19％(P<0.01),左心室压力上升最大速率[(dp/dt)_(max)]减少10％(P<0.01)和21％(P<0.01)。提示非创伤性指标虽然没有创伤性指标敏感,但也可以较好地反映冠脉缺血时心脏功能的变化。同时指出PEP/LVET的这些变化与CBF,LVSP及(dp/dt)_(max)呈显著负相关,因而可用PEP/LVET估算创伤性心功能测定指标。
The author of coronary artery micronizer caused by 11 left thoracotomy left stenosis varying degrees of stenosis. The traumatic and non-traumatic left ventricular systolic function was measured and compared in normal, critical stenosis and severe stenosis. Non-traumatic cardiac function was significantly increased by 5% (P <0.05) and 17% (P <0.01) at the pre-ejection stage in ventricular ejection time (PEP / LVET) at critical and severe stenosis. Traumatic indices coronary artery blood flow (CBF) decreased 26% (P <0.01) and 62% (P <0.01), LVSP decreased 6% (P <0.05) and 19% 0.01), and the maximum rate of left ventricular pressure (dp / dt) _ (max) decreased by 10% (P <0.01) and 21% (P <0.01). It is suggested that the non-invasive index is not sensitive to the traumatic index, but it can also better reflect the change of cardiac function during coronary ischemia. At the same time, it was pointed out that these changes of PEP / LVET were significantly and negatively correlated with CBF, LVSP and (dp / dt) _ (max), therefore PEP / LVET could be used to evaluate the traumatic cardiac function.