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目的探讨新生儿败血症的病原菌分布及耐药性,以利于临床合理使用抗生素。方法采用回顾性研究方法对北京市和平里医院儿科2002年1月至2007年12月收治的56例新生儿败血症病例的血培养菌株和细菌耐药结果进行分析。结果均为单一菌种生长,其中以凝固酶阴性葡萄球菌(CNS)为主,对青霉素和头孢类抗生素耐药性高(60%～100%),亚胺培南耐药率低(38%～44%),对万古霉素无耐药,革兰阴性杆菌对头孢三代耐药率较低(25%～60%),亚胺培南无耐药。结论凝固酶阴性葡萄球菌是新生儿败血症最常见的病原菌,对常用抗菌药物有不同程度的耐药;全面了解和掌握本地区细菌种类和耐药性变化有利于提高新生儿科抗感染治疗的质量,降低耐药性的发生。
Objective To explore the distribution and drug resistance of pathogens in neonatal sepsis to facilitate the rational use of antibiotics in clinic. Methods A retrospective study was carried out to analyze the blood culture bacterial strains and bacterial resistance of 56 cases of neonatal sepsis treated in Hepingli Hospital of Pediatrics from January 2002 to December 2007. The results were single strain growth, mainly coagulase negative staphylococcus (CNS), penicillin and cephalosporin antibiotic resistance (60% ~ 100%), imipenem resistance rate is low (38% ~ 44%), no resistance to vancomycin, low resistance rate (25% -60%) to Gram-negative bacilli to cephalosporin, and no resistance to imipenem. Conclusion Coagulase-negative staphylococci are the most common pathogens in neonatal sepsis and have different degrees of resistance to commonly used antimicrobial agents. To understand and master the changes of bacterial species and drug resistance in the region is conducive to improving the quality of neonatal anti-infective treatment, Reduce the occurrence of drug resistance.