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目的:观察滋肾宁心汤治疗子宫内膜异位症术后患者应用Gn RH-a致类绝经期症状的临床疗效。方法:选取临床上手术病理确诊为子宫内膜异位症的患者90例,随机分为3组,每组30例。所有患者均于术后月经周期第1天给予Gn RH-a注射(戈舍瑞林3.6mg皮下注射),每4周注射1次。对照组于第28天继续给予Gn RH-a注射,研究1组于第28天继续给予Gn RH-a注射的同时加用坤泰胶囊;研究2组于第28天继续给予Gn RH-a注射的同时加用中药方滋肾宁心汤,比较3组患者治疗前后中医临床症状体征、绝经症状评分及记录不良反应。结果:3组患者治疗后第12周相比,研究1组及研究2组中医临床症状体征积分均较同组治疗前明显下降,具有显著性差异(P<0.05);治疗后第12周,3组患者Kupermann评分均较同组治疗前显著升高(P<0.05),且按对照组、研究1组、研究2组的顺序依次呈下降趋势,具有显著性差异(P<0.05);对照组治疗期间出现了一系列的类绝经期症状,研究1组及研究2组治疗期间出现的类绝经期症状发生例数明显低于对照组。结论:滋肾宁心汤治疗子宫内膜异位症术后患者应用Gn RH-a致类绝经期症状的疗效确切,可有效缓解Gn RH-a所引起的低雌激素症状,且疗效优于坤泰胶囊。
Objective: To observe the clinical efficacy of Zishen Ningxin Decoction in treating postmenopausal symptoms of Gn RH-a patients after endometriosis. Methods: Totally 90 patients with clinically diagnosed endometriosis were randomly divided into 3 groups (n = 30 in each group). All patients were given Gn RH-a injection (goserelin 3.6 mg subcutaneously) on the first day of the menstrual cycle and injected once every four weeks. The control group was given Gn RH-a injection on the 28th day, and the study group 1 continued to receive Gn RH-a injection on the 28th day with the use of Gutta-percha injection. In the study group 2, Gn RH-a injection was continued on the 28th day While adding traditional Chinese medicine Fang Zishen Decoction, comparing the clinical symptoms and signs, menopausal symptom scores and adverse reactions of the three groups before and after treatment. Results: Compared with the same group before treatment, the scores of clinical symptoms and signs of the study group 1 and study group 2 were significantly decreased at the 12th week after treatment (P <0.05). At the 12th week after treatment, The Kupermann scores of three groups were significantly higher than those of the same group before treatment (P <0.05). According to the control group, one group was studied. The order of the two groups showed a downward trend, with significant difference (P <0.05) During the treatment period, a series of symptoms of menopausal symptoms appeared. The incidence of menopausal symptoms in study group 1 and study group 2 was significantly lower than that of the control group. Conclusion: Zishen Ningxin Decoction for postoperative patients with endometriosis postoperative Gn RH-a-induced menopausal symptoms of the exact effect can effectively alleviate Gn RH-a caused by low estrogen symptoms, and the effect is better than Kuntai capsules.