目的 :建立复方甲苯咪唑片的RP -HPLC含量测定方法。方法 :采用RP -C8( 2 2 0mm× 2 1mm) 5μm不锈钢柱 ,以甲醇 -0 5%醋酸铵作流动相 ,pH =5 0 0 ,检测波长 2 2 0nm。 结果 :甲苯咪唑和盐酸左旋咪唑平均回收率分别为 99 2 1 %和 99 71 % ,RSD <1 2 % (n =5)。结论 :方法简便、灵敏、准确 ,对 1 0个批号的样品进行了分析 ,测定结果与中国药典法测定结果基本一致 Objective: To establish a method for determination of RP-HPLC in compound mebendazole tablets. METHODS: RP-C8 (220mm × 2 1mm) 5μm stainless steel column was used. The mobile phase consisted of methanol-5% ammonium acetate, pH = 500 and detection wavelength of 220 nm. RESULTS: The mean recoveries of mebendazole and levamisole were 99 2 1% and 99 71%, respectively, with RSD <1 2% (n = 5). Conclusion: The method is simple, sensitive and accurate. The samples of 10 batches were analyzed, and the results were in good agreement with the results of Chinese Pharmacopoeia