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目的肝癌高发区 HBs Ag阳性及阴性青少年血清透明质酸 (HA)、 型胶原 ( - C)水平比较分析。方法用放免法测定 1 4 4例 1 6岁和 1 9岁 HBs Ag阳性及阴性青少年血清 HA、 - C。结果 HA和 - C在 1 6岁阳性组及 1 6岁阴性组中的异常率和均值都无显著差异。但 1 9岁阳性组 HA的异常率 (68.2 % )和均值〔(1 0 5.0± 41 .3) ng/ ml〕明显高于 1 9岁阴性组〔2 7.3%和 (58± 2 1 .5) ng/ ml〕;1 9岁阳性组和阴性组的 - C异常率和均值无显著差异。结论 HA可作为初步反映年龄大于 1 6岁青年的肝纤维化随访检测指标之一
Objective To compare and analyze the levels of serum hyaluronic acid (HA) and collagen (- C) in HBsAg-positive and -negative adolescents with high incidence of HCC. Methods 144 cases of HBsAg-positive and -negative adolescent serum HA, - C were enrolled in 114 cases of 16-year-old and 19-year-olds. Results There was no significant difference in the abnormal rates and mean values of HA and - C between the 16-year-old positive group and the 16-year negative negative group. However, the abnormality rate (68.2%) and mean 〔(105.0 ± 41.3) ng / ml〕 in HA group were significantly higher than those in the 19-year-old negative group 〔2 7.3% vs 58 ± 21.5 ) ng / ml]; there was no significant difference in the abnormal rate and mean value of - C between the positive group and the negative group at 19 years old. Conclusion HA can be used as one of the primary indicators of follow-up of liver fibrosis in children over 16