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目的探讨育龄人群强化麻疹疫苗(MV)注射前后麻疹免疫水平,进一步分析育龄男女麻疹免疫水平对消除麻疹的影响,为最终实现消除麻疹目标提供科学依据。方法选择本院22-35岁育龄医护人员60名,观察MV注射前及注射后26个月的麻疹免疫水平的差异,并采用酶联免疫吸附试验(ELISA),对其MV免疫前后的血清分别检测IgM和IgG抗体。结果育龄男女接种MV前后χ2检验结果:在1 200水平上,χ2=7.32,P<0.05;在1 800水平,χ2=10.25,P<0.05;注射前后麻疹免疫水平有统计学差异。结论育龄男女或夫妻双方孕前及时、安全接种MV,既可提高育龄人群麻疹抗体水平,同时也可提高出生8月龄婴儿麻疹疫苗初免之前胎传麻疹抗体水平,从而有效降低25岁以上人群及8月龄内婴儿麻疹发病,达到“一代免疫,两代受益”的效果,对阻断“双相移位”具有重要意义。
Objective To explore the level of measles immunity before and after measles vaccine (MV) injection in children of childbearing age and to further analyze the impact of immunization against measles in male and female childbearing age to eliminate measles and provide a scientific basis for the ultimate goal of eliminating measles. Methods 60 nurses of childbearing age aged 22-35 were selected to observe the difference of measles immunity before MV injection and at 26 months after injection. The serum levels of MV before and after immunization were respectively measured by enzyme linked immunosorbent assay (ELISA) Detection of IgM and IgG antibodies. Results The results ofχ2 test before and after MV inoculation of men and women of childbearing age showed that at 1 200 level, χ2 = 7.32, P <0.05; at 1800 level, χ2 = 10.25, P <0.05; measles immune level before and after injection was statistically different. Conclusions Both males and females of childbearing age or the safe vaccination of both husband and wife before pregnancy can improve the antibody level of measles in the childbearing age group and enhance the level of measles antibody before birth of measles vaccine at the age of 8 months, The incidence of measles in 8 months of age, to achieve “one generation of immunity, two generations benefit ” effect, blocking “biphasic shift ” is of great significance.