苯巴比妥对ICR小白鼠的急性毒性及药效均呈明显的昼夜节律性差异,夜间用药的毒性高于白昼用药,死亡峰值时在21:29,反之,白昼用药催眠作用起效快,维持时间久,血药浓度高,半衰期短,在较低的血药浓度下仍能维持有效的催眠作用,结果表明苯巴比妥的毒性及药效的昼夜节律性差异并非完全取决于其药物动力学的昼夜差异,而可能是主要依赖于动物的敏感性的昼夜差异。 Phenobarbital on ICR mice acute toxicity and efficacy showed significant differences in circadian rhythm, nighttime drug toxicity than daytime medication, the peak death at 21:29, conversely, the hypnotic effect of daytime medication onset fast, Maintained for a long time, high blood concentration, short half-life, at low plasma concentrations can still maintain an effective hypnotic effect, the results show that the toxicity and efficacy of phenobarbital circadian differences do not depend entirely on their drug The diurnal variation in kinetics may be a diurnal difference that mainly depends on the sensitivity of the animal.