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静脉输注给药是临床常用的给药方法之一、在以往只当做一种给药途经,仅注意输注药物对人体刺激程度或多种药物混合输注时是否稳定等。近年来药物动力学的发展,证实药物的疗效和毒副作用是血药浓度的函数。故临床用恒速静脉输注给药时,一定要使机体产生的血药浓度维持在有效治疗范围内,并要求维持适当的时间,才能保证药物的临床治疗作用。静脉滴注给药时体内药动学方程恒速静脉输注给药是指被输注的药物以恒定的速度注入机体内的给药方法,进入机体内的药物表现为一级消除时,药物体内动力学经时方程如下所述。当静脉输注的药物在机体内的隔室模型为单室时,稳态前,稳态时,停止输注后的经时
Intravenous administration is one of the commonly used methods of drug delivery in the past, only in the past as a route of administration, only pay attention to the degree of human infusion of drugs to stimulate the body or a variety of drugs mixed infusion stability. In recent years, the development of pharmacokinetics confirms the efficacy of drugs and side effects as a function of plasma concentration. Therefore, the clinical use of constant-speed intravenous infusion of drugs, we must make the body produce plasma concentrations remain valid treatment range, and require maintenance of appropriate time to ensure the clinical therapeutic effect of drugs. Intravenous Pharmacokinetic Equation in Intravenous Infusion Constant velocity intravenous infusion refers to the infusion of drugs injected into the body at a constant rate of administration, into the body of the drug showed a level of elimination, the drug The in vivo kinetic time equations are described below. When the intravenous infusion of drugs in the body compartment model for the single-chamber, steady-state before and after the steady-state, stop after the infusion of time