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实验肝癌研究表明从癌组织可获得与AFP活性相似的癌胚蛋白γ-谷氨酰转肽酶(γ-GTP)。一些肝细胞癌患者γ-GTP活性增高,表明γ-GTP可能出现于肝细胞癌变期,并由癌细胞产生。作者应用聚丙烯酰胺梯度琼脂电泳作血清γ-GTP分离。224例各种肝胆疾病患者血清的γ-GTP同功酶可分成12个区带,称为Ⅰ、Ⅱ、Ⅱ′、Ⅲ、Ⅳ、Ⅴ、Ⅵ、Ⅶ_a、Ⅶ_b、Ⅶ_c、Ⅷ_a和Ⅷ_b。区带Ⅰ、Ⅱ和Ⅶ_b分别见于白蛋白、铜蓝蛋白、α_2-巨球蛋白区附近。
Experimental liver cancer studies have shown that cancerous protein γ-glutamyl transpeptidase (γ-GTP) similar to AFP activity can be obtained from cancer tissue. Some patients with hepatocellular carcinoma have increased γ-GTP activity, suggesting that γ-GTP may be present in the hepatocarcinogenesis stage and produced by cancer cells. The authors used polyacrylamide gradient agar electrophoresis for serum γ-GTP separation. The serum γ-GTP isoenzymes in 224 patients with various hepatobiliary diseases can be divided into 12 zones called I, II, II’, III, IV, V, VI, VII_a, VII_b, VII_c, VIII_a, and VIII_b. Zones I, II, and VII_b are found near albumin, ceruloplasmin, and α_2-macroglobulin regions, respectively.