论文部分内容阅读
目的探讨糖化血红蛋白(HbA1c)在妊娠期糖尿病(GDM)筛查中的临床价值。方法对GDM患者和正常孕妇各50例,分别检测HbA1c水平,空腹血糖,50 g葡萄糖筛查试验(GCT)和口服75 g葡萄糖耐量试验(OGTT)。使用ROC曲线对GCT和HbA1c作为妊娠期糖尿病的筛查指标进行统计学分析。结果 GDM患者HbA1c水平和GCT均高于正常孕妇,两组有显著性差异,P<0.01。使用ROC曲线分析,GCT取7.8 mmol/L时,敏感性和特异性分别为68.1%~73.8%和62%~65.3%;HbA1c取5.9%,敏感性和特异性分别为73.2%~80.1%和79.5%~83.1%。结论 HbA1c可以作为妊娠期糖尿病筛查的指标,但需要进一步扩大临床研究,验证切点值。
Objective To investigate the clinical value of glycosylated hemoglobin (HbA1c) screening in gestational diabetes mellitus (GDM) screening. Methods Fifty patients with GDM and normal pregnant women were enrolled in this study. HbA1c level, fasting blood glucose, 50 g glucose screening test (GCT) and oral glucose tolerance test (OGTT) were tested respectively. ROC curves were used to analyze GCT and HbA1c as markers of gestational diabetes mellitus. Results The levels of HbA1c and GCT in GDM patients were significantly higher than those in normal pregnant women, with significant difference between the two groups (P <0.01). Using ROC curve analysis, the sensitivity and specificity were 68.1% -73.8% and 62% -65.3% when GCT was 7.8 mmol / L, 5.9% for HbA1c, and the sensitivity and specificity were 73.2% -80.1% and 79.5% ~ 83.1%. Conclusion HbA1c can be used as a marker of gestational diabetes screening, but further clinical studies are needed to verify the cut-off value.