慢性阻塞性肺病(COPD)患者长期处于低氧和高碳酸血症状态,传统给氧方法是采用持续低流量吸入,以防呼吸抑制,加重低氧血症和二氧化碳(CO_2)潴留,即使在COPD急性发作期,患者严重缺氧也禁用高浓度的氧气吸入。我们对一组急性发作期的COPD患者给予较高浓度的氧气吸入,以观察其对呼吸的影响。材料和方法 COPD急性发作期37例(男31,女6),年龄42～79岁,平均61岁。全部患者动脉血氧分压(PaO_2)均低于10.67kPa,其中Ⅱ型呼吸衰竭19例(PaO_2<8kPa,PaCO_2>6.7khPS)。 Chronic obstructive pulmonary disease (COPD) in patients with long-term hypoxia and hypercapnia state, the traditional oxygen method is the use of sustained low-flow inhalation to prevent respiratory depression, increased hypoxemia and carbon dioxide (CO2) retention, even in COPD Acute exacerbation, patients with severe hypoxia also disable high concentrations of oxygen inhalation. We administered a higher concentration of oxygen inhalation to a group of COPD patients with acute exacerbation to observe their effects on breathing. Materials and Methods 37 cases of acute exacerbation of COPD (male 31, female 6), aged 42 to 79 years, mean 61 years. All patients had PaO_2 less than 10.67kPa, among which 19 were Type Ⅱ respiratory failure (PaO_2 <8kPa, PaCO_2> 6.7khPS).