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Background:Patients with hyperplastic polyposis coli syndrome(HPCS)have a propensity to develop colorectal carcinoma(CRC).Patients and Methods:Details were retrieved from the files of patients attending our hospital between 1988 and 2004 who fulfilled the World Health Organization criteria for HPCS.Results:Over a period of 16 years,10 cases of HPCS were identified at our hospital(0.625 cases/year or one case every 1.6 years).A mean of 40.3 hyperplastic polyps per patient were found(range 6-159).Other colorectal lesions were found as follows:two patients each had one mixed polyp;there were 15 serrated adenomas in eight patients;and there were 30 tubular,tubulovillous,or villous adenomas in eight patients.Among the 10 patients with HPCS,seven developed a CRC.Of the four villous adenomas,three were associated with a CRC,but only one of the 15 serrated adenomas was associated with a CRC.The pathway of cancer evolution in HPCS patients remains unresolved.Conclusions:Similarly to our results,a review of the literature indicates a high incidence of CRCs in HPCS patients.These patients are at a high risk of developing a CRC and should therefore receive regular colonoscopic surveillance.
Background: Patients with hyperplastic polyposis coli syndrome (HPCS) have a propensity to develop colorectal carcinoma (CRC). Pats and Methods: Details were retrieved from the files of patients attending our hospital between 1988 and 2004 who fulfilled the World Health Organization criteria for HPCS . Results: Over a period of 16 years, 10 cases of HPCS were identified at our hospital (0.625 cases / year or one case every 1.6 years). A mean of 40.3 hyperplastic polyps per patient were found (range 6-159) .Other There were 30 serrated adenomas in eight patients; and there were 30 tubular, tubulovillous, or villous adenomas in eight patients. Among the 10 patients with HPCS, seven developed a CRC .Of the four villous adenomas, three were associated with a CRC, but only one of the 15 serrated adenomas was associated with a CRC. The pathway of cancer evolution in HPCS patients remains unresolved. Conclusions: even to our results , a review of the literature indicates a high incidence of CRCs in HPCS patients. These patients are at a high risk of developing a CRC and should therefore receive regular colonoscopic surveillance.