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目的:探讨ANA阴性的SLE患者临床及肾脏病理特征。方法:对至少有两年随访纪录的363例SLE患者的病例资料进行回顾分析。结果:35例ANA阴性(9.6%),328例ANA阳性(90.4%),与ANA阳性组比较,ANA阴性组光过敏(37.1%)及抗SSA抗体(60.0%)发生率较高,而肾损害(57.1%)、关节炎(42.9%)及抗ds-DNA抗体(42.9%)的发生率则较低;其中68例患者进行了肾穿刺活检,两组肾脏病理类型总体分布无显著差异(P>0.05)。结论:ANA阴性的SLE患者光过敏常见,抗SSA抗体阳性率较高,而肾损害相对少见。
Objective: To investigate the clinical and renal pathological features of ANA-negative SLE patients. Methods: The data of 363 SLE patients with at least two years of follow-up were retrospectively analyzed. Results: ANA negative (9.6%) was detected in 35 cases and positive in 328 cases (90.4%). Compared with ANA positive group, ANA negative group had a higher incidence of photosensitivity (37.1%) and anti-SSA antibody (60.0% Lesions (57.1%), arthritis (42.9%), and anti-dsDNA antibodies (42.9%) were lower in incidence. Of the 68 patients who underwent renal biopsy, there was no significant difference in the overall distribution of kidney pathology P> 0.05). Conclusion: ANA negative SLE patients with common light allergy, anti-SSA antibody positive rate, while kidney damage is relatively rare.