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目的观察微创经皮肾镜联合输尿管软镜治疗肾结石的疗效及血清学变化。方法将220例肾结石患者随机分为试验组和对照组各110例。试验组给予微创经皮肾镜联合输尿管软镜治疗,对照组仅给予微创经皮肾镜治疗。观察2组患者治疗效果及血清尿激酶水平变化。结果试验组患者治疗总有效率为96.36%高于对照组的83.64%,差异有统计学意义(P<0.05)。试验组患者治疗后并发症发生率低于对照组,差异亦有统计学意义(P<0.05)。2组患者治疗前血清尿激酶水平相近,差异无统计学意义(P>0.05)。治疗后2组患者血清尿激酶水平均有增高,且试验组高于对照组,差异均有统计学意义(P<0.05)。结论微创经皮肾镜联合输尿管软镜治疗肾结石具有良好的治疗效果,并提高血清尿激酶水平。
Objective To observe the efficacy and serological changes of minimally invasive percutaneous nephrolithotomy combined with ureteroscopic treatment of renal calculus. Methods 220 cases of kidney stones were randomly divided into test group and control group of 110 cases. The experimental group was treated with minimally invasive percutaneous nephrolithotomy combined with ureteroscopy, while the control group received minimally invasive percutaneous nephrolithotomy. The therapeutic effect and the level of serum urokinase in two groups were observed. Results The total effective rate of treatment group was 96.36% higher than 83.64% of control group, the difference was statistically significant (P <0.05). The incidence of postoperative complications in the experimental group was lower than that in the control group, with significant difference (P <0.05). The levels of serum urokinase in two groups before treatment were similar, with no significant difference (P> 0.05). After treatment, serum urokinase levels in both groups increased, and the experimental group was higher than the control group, the difference was statistically significant (P <0.05). Conclusion Minimally invasive percutaneous nephrolithotomy combined with ureteroscopic treatment of kidney stones has a good therapeutic effect, and increase serum urokinase levels.