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目的探讨髂内动脉灌注化疗前后P53、bcl-2、血管内皮生长因子(VEGF)在浸润性膀胱肿瘤组织中表达的意义。方法采用免疫组化法对8例浸润性膀胱肿瘤患者动脉灌注化疗前后血清中的P53、bcl-2、VEGF进行检测。结果灌注前P53的表达率为50%(+～++),bcl-2的表达率为50%(+～+++),VEGF的表达率为50%(+～++);灌注后P53的表达率为50%(+～++),bcl-2为阴性,VEGF的表达率为50%(+)。结论灌注化疗能降低肿瘤标记物的表达,检测P53、bcl-2、VEGF对肿瘤治疗的有效性和预后判断有重要意义。
Objective To investigate the significance of expression of P53, bcl-2 and vascular endothelial growth factor (VEGF) in invasive bladder tumor before and after internal iliac artery chemotherapy. Methods The levels of P53, bcl-2 and VEGF in 8 patients with invasive bladder tumor before and after arterial infusion chemotherapy were detected by immunohistochemistry. Results The expression of bcl-2 was 50% (+ ~ +++) and the expression of VEGF was 50% (+ ~ ++) before perfusion. The expression rate of P53 was 50% (+ ~ ++), bcl-2 was negative, VEGF expression was 50% (+). Conclusion Perfusion chemotherapy can reduce the expression of tumor markers. Detection of P53, bcl-2, VEGF is of great significance for the treatment of cancer and prognosis.