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探讨微血管量在浸润性乳腺癌中的意义。方法应用亲和素－生物素－过氧化物酶复合物（ＡＢＣ）免疫组织化学方法对７０例乳腺浸润性导管癌作荆豆素（ＵＥＡ１）和第八因子（Ｆ８）染色，并对癌组织中的微血管计数。采用Ｌｏｇｉｓｔｉｃ多因素回归分析法进行分析。结果淋巴结有转移组和无转移组间微血管计数有极显著的差异（Ｐ＜０．０００１）。淋巴结有转移组的微血管密度显著高于无淋巴结转移组（Ｐ＜０．０００１）。肿瘤的组织学分级与微血管计数及淋巴结转移显著相关（Ｐ＜０．０５和Ｐ＜０．０００１）。术后健在组患者和带癌生存、死亡组患者的微血管计数有显著差异（Ｐ＜０．０５）。结论浸润性乳腺癌内的微血管量是一个独立的有重要意义的预后因素，与淋巴结转移、患者的生存状况密切相关。
To investigate the significance of microvascular volume in invasive breast cancer. METHODS: Immunohistochemistry of avidin-biotin-peroxidase complex (ABC) was used to stain 70 cases of invasive ductal carcinoma of breast (HUA) (UrA1) and eighth factor (F8), and to identify the cancer tissue. Microvascular counts in the. Logistic multivariate regression analysis was used for analysis. Results There was a significant difference in microvessel counts between the metastatic and non-metastatic lymph nodes (P<0.0001). The microvessel density in the lymph node metastasis group was significantly higher than that in the no lymph node metastasis group (P<0.0001). The histological grade of the tumor was significantly associated with microvessel count and lymph node metastasis (P<0.05 and P<0.0001). There was a significant difference in the microvessel counts between the postoperative patients in the active group and those with cancer survival and death (P<0.05). Conclusion The invasive breast cancer microvessel volume is an independent and important prognostic factor, which is closely related to the lymph node metastasis and the survival status of the patients.