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目的 探讨米托蒽醌 ,5 FU ,大剂量的CF方案、NFL方案在治疗晚期发生转移的乳腺癌中的疗效及毒副作用。方法 75例患者接受NFL方案治疗 ,米托蒽醌 12mg/m静推第 1天 ,CF 30 0mg静滴第 1～ 5天 ,2小时内滴完后静滴 5 FU 35 0mg/m第 1～ 5天。另外 75例接受CMF方案 ,CTX 6 0 0mg/m静推第 1天 ,MTX 40mg/m静推第 1天 ,5 FU 6 0 0mg/m静滴第 1天 ,均应用三周期以上。 结果 NFL的缓解率明显高于CMF方案的缓解率 (前者为 5 8.6 3 % ,后者为 30 .7% ,P <0 .0 5 ) ,中位生存期两者相似。毒副作用都能耐受。结论 NFL方案是治疗发生转移的晚期乳腺癌的一种较佳方案 ,对晚期乳腺癌有较高的缓解率和较低的毒副作用。
Objective To investigate the efficacy and toxic side effects of mitoxantrone, 5 FU, high-dose CF regimen and NFL regimen in the treatment of metastatic breast cancer. Methods Seventy-five patients were treated with NFL regimen, mitoxantrone 12 mg/m intravenous injection on the first day, CF 30 0 mg intravenous infusion on the first 1-5 days, and intravenous infusion after 2 hours of instillation 5 FU 35 0 mg/m 1 5 days. Another 75 patients underwent CMF regimen, CTX 600 mg/m intravenous injection on the first day, MTX 40 mg/m intravenous injection on the first day, and 5 FU 600 mg/m intravenous injection on the first day, all of which were applied over three cycles. Results The remission rate of NFL was significantly higher than that of CMF (the former was 58.6 3%, the latter was 30.7%, P<0.05), and the median survival was similar. Toxic side effects can tolerate. Conclusion The NFL regimen is a better treatment for metastatic advanced breast cancer. It has higher remission rate and lower side effects for advanced breast cancer.