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目的探讨系统性红斑狼疮(SLE)患者血清IL-10和IL-18的表达及其与疾病活动的关系。方法应用ELISA法检测104例SLE患者和100例健康体检者血清IL-10和IL-18的水平,其中SLE患者根据疾病活动性指数(SLEDAI)评分标准分为活动组(56例)和缓解组(48例),比较各组结果的差异,并分析SLEDAI与IL-10和IL-18的相关性。结果 SLE组IL-10和IL-18水平分别为(18.25±3.66)、(582.61±65.28)pg/ml,明显高于对照组的(7.12±2.36)、(186.24±60.39)pg/ml,差异有统计学意义(P<0.01);SLE活动组IL-10和IL-18水平分别为(25.98±4.75)、(683.72±62.48)pg/ml,高于缓解组的(14.67±3.21)、(493.51±69.17)pg/ml,差异亦有统计学意义(P<0.01);SLE患者血清IL-10和IL-18水平与SLEDAI呈正相关(P<0.05)。结论 IL-10和IL-18在SLE发病机制中发挥重要作用,而且与疾病活动性相关。
Objective To investigate the expression of IL-10 and IL-18 in patients with systemic lupus erythematosus (SLE) and its relationship with disease activity. Methods Serum levels of IL-10 and IL-18 in 104 SLE patients and 100 healthy controls were detected by ELISA. The SLE patients were divided into active group (56 cases) and remission group according to SLEDAI score (48 cases). The differences between the groups were compared and the correlation between SLEDAI and IL-10 and IL-18 was analyzed. Results The levels of IL-10 and IL-18 in SLE group were (18.25 ± 3.66) and (582.61 ± 65.28) pg / ml, which were significantly higher than those in control group (7.12 ± 2.36 and 186.24 ± 60.39) pg / ml (P <0.01). The levels of IL-10 and IL-18 in SLE group were (25.98 ± 4.75) and (683.72 ± 62.48) pg / ml respectively, higher than those in remission group (14.67 ± 3.21 and 493.51 ± 69.17) pg / ml, the difference was also statistically significant (P <0.01). The levels of IL-10 and IL-18 in SLE patients were positively correlated with SLEDAI (P <0.05). Conclusion IL-10 and IL-18 play an important role in the pathogenesis of SLE and are related to disease activity.