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目的 观察氧化修饰低密度脂蛋白 (Ox-LDL )与颈动脉粥样硬化 (CAS)程度的关系。方法 通过复式超声确诊 CAS患者 78例 ,并根据 CAS程度将患者分为轻、重两组。对照组 32例。采用硫代巴比妥酸反应物法测定 Ox-LDL含量。结果 CAS组 Ox-L DL含量为 (1.46± 0 .46 ) nmol/ml。 CAS轻组 Ox-LDL含量为 (1.30± 0 .37) nmol/ml。 CAS重组 Ox-L DL含量为 (1.88± 0 .6 0 ) nmol/ml。对照组 Ox-LDL含量为 (0 .39± 0 .2 5 ) nmol/ml。 CAS组 Ox-LDL含量显著高于对照组 (P<0 .0 1)。 CAS重组 Ox-LDL含量显著高于 CAS轻组 (P<0 .0 1)。结论 Ox-LDL 水平可反映 CAS的程度。
Objective To investigate the relationship between oxidized low density lipoprotein (Ox-LDL) and carotid atherosclerosis (CAS). Methods 78 patients with CAS were diagnosed by duplex ultrasonography and divided into mild and severe groups according to the degree of CAS. Control group of 32 cases. The content of Ox-LDL was determined by thiobarbituric acid reactant method. Results The content of Ox-L DL in CAS group was (1.46 ± 0.46) nmol / ml. CAS light Ox-LDL content (1.30 ± 0.37) nmol / ml. The content of CAS recombinant Ox-L DL was (1.88 ± 0.60) nmol / ml. The content of Ox-LDL in the control group was (0.39 ± 0.25) nmol / ml. Ox-LDL content in CAS group was significantly higher than that in control group (P <0.01). The level of Ox-LDL in CAS recombinant was significantly higher than that in CAS (P <0.01). Conclusion The level of Ox-LDL can reflect the degree of CAS.