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目的对比观察应用三联疗法根除幽门螺杆菌(Hp)治疗消化性溃疡与单纯应用质子泵抑制剂治疗消化性溃疡的疗效。方法将100例消化性溃疡患者分成AB两组。A组为对照组50例,单纯口服奥美拉唑,4周为一疗程;B组为治疗组50例,在口服奥美拉唑的基础上加用克拉霉素和羟氨苄青霉素同时口服,2周为一疗程。结果A组治疗四周,溃疡愈合30例,治疗8周,溃疡共愈合42例,5例好转,3例未愈。随访半年,半年内复发33例,1年内复发50例。B组治疗2周,溃疡愈合49例,1例好转。继续治疗1周愈合。随访半年,复发0例,1年随访,复发1例。结论三联疗法根除幽门螺杆菌治疗消化性溃疡比单纯应用质子泵抑制剂疗程短,治愈率高、复发率低、费用低。
Objective To compare the efficacy of triple therapy in the treatment of peptic ulcer with Helicobacter pylori (Hp) and proton pump inhibitor alone in the treatment of peptic ulcer. Methods One hundred patients with peptic ulcer were divided into two groups. A group of 50 patients in the control group, oral omeprazole alone, 4 weeks for a course of treatment; B group for the treatment group 50 cases, oral omeprazole based on the addition of clarithromycin and amoxicillin at the same time oral, 2 weeks for a course of treatment. Results A group of treatment of four weeks, 30 cases of ulcer healing, treatment of 8 weeks, a total of 42 cases of ulcer healing, 5 cases improved, 3 cases healed. Follow-up six months, 33 cases relapsed within six months, 50 cases relapsed in one year. B group for 2 weeks, 49 cases of ulcer healing, 1 case improved. Continue treatment 1 week healing. Follow-up six months, 0 cases of recurrence, 1-year follow-up, 1 case of recurrence. Conclusions Triple therapy in the treatment of peptic ulcer with Helicobacter pylori is shorter than the simple application of proton pump inhibitor, with high cure rate, low recurrence rate and low cost.