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目的概述临床上常见的能够引起糖代谢紊乱的药物,为临床医生提供警示。方法结合临床实践,并结合文献,概述几类常见的可引起糖代谢紊乱的药物的种类(按《新编药物学》第16版分类)、发病机制、临床表现和防治方法。结果与结论能够引起药源性糖代谢紊乱的药物有抗微生物类药物、激素类药物、抗精神病药物、噻嗪类利尿剂、免疫调节剂、β-受体阻滞剂及其他药物。世界范围内的糖代谢紊乱人群逐年增多,糖代谢紊乱包括血糖升高和血糖降低。近年来药源性糖代谢紊乱不良反应的病例也屡见报道,特别是加替沙星事件更是给我们敲响了警钟。药源性糖代谢紊乱不仅会给临床治疗带来干扰,严重时甚至可威及高危人群的生命安全,因此我们应该高度重视药源性糖代谢紊乱,对于引起药源性糖代谢紊乱的药物,应有一个全面的掌握,谨慎使用这些药物。
Objective To summarize the commonly used clinical drugs that can cause disorders in glucose metabolism and provide clinicians with a warning. Methods Combined with clinical practice and literature, several common types of drugs that can cause disorders of glucose metabolism (classified according to the 16th edition of New Pharmacology), pathogenesis, clinical manifestations and prevention and treatment methods were summarized. RESULTS AND CONCLUSIONS Drugs that can cause drug-induced glucose metabolism include antimicrobials, hormonal drugs, antipsychotics, thiazide diuretics, immunomodulators, beta-blockers and other drugs. The worldwide population with disorders of glucose metabolism is increasing year by year. The disorders of glucose metabolism include the rise of blood sugar and the decrease of blood sugar. In recent years, drug-induced adverse effects of glucose metabolism disorders are also frequently reported cases, especially gatifloxacin incident is to sounded the alarm. Drug-induced glucose metabolism disorder will not only bring clinical treatment interference, even in severe cases can threaten the lives of high-risk groups, so we should attach great importance to drug-induced glucose metabolism disorders, drug-induced metabolic disorders caused by drugs, There should be a comprehensive grasp of these drugs with caution.