Flestolol是一种非选择性的强效超短效的β阻滞剂,在体内能被血浆酯酶类迅速水解,消除半衰期为约6.5分钟。体内代谢和处置 Flestolol可被血浆中的酯酶类所代谢,水解产物为邻氟苯甲酸和氨基二醇,均无β阻滞活性。动物体内药理学在离体心房组织内,Flestolol的作用较心得安强约3倍,或为Esmolol的10倍以上。在麻醉犬体内,Flestolol对异丙肾上腺 Flestolol is a non-selective and potent, very short-acting beta-blocker that is rapidly hydrolyzed by plasma esterases in vivo with an elimination half-life of approximately 6.5 minutes. In Vivo Metabolism and Management Flestolol is metabolized by esterases in plasma and the products of hydrolysis are o-fluorobenzoic acid and aminodiols, with no beta-arrest activity. In vivo Pharmacology In isolated atrial tissue, Flestolol is about 3 times more potent and 10 times more potent than Esmolol. In an anesthetized dog, Flestolol is isoproterenol