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目的：通过观察非洛地平、卡托普利、叶酸及 B 族维生素联合干预 H 型高血压患者血压、颈动脉内膜中层厚度（CAIMT）及血清同型半胱氨酸（Hcy）水平变化，探讨药物联合干预 H 型高血压的临床疗效。方法对86例 H 型高血压患者实施非洛地平、卡托普利、叶酸及 B 族维生素联合干预8周，对比分析干预前后血压、CAIMT 及血清 Hcy 水平变化。结果观察组干预前收缩压（ SBP）、舒张压（ DBP）、CAIMT 及血清 Hcy 水平[（168.9±10.4）mm Hg，（92.5±11.3）mm Hg，（24.7±5.3）μmol/ L，0.98±0.19]均显著高于对照组[（123.5±6.6）mm Hg，（71.8±7.9）mm Hg，（9.8±2.7）μmol/ L，0.57±0.14）（ P <0.01）]，干预后 SBP、DBP、CAIMT 及血清 Hcy 水平[（130.2±8.9）mm Hg，（78.7±8.6）mm Hg，（10.9±4.2）μmol/ L，0.76±0.13]均显著低于干预前（P <0.01）。药物联合干预 H 型高血压患者的总有效率为94.2%（81/86）。结论非洛地平、卡托普利、叶酸及 B 族维生素联合干预 H 型高血压患者，可显著改善血压、颈动脉粥样硬化及血液 Hcy 水平，临床疗效显著。“,”Objective By observing the change of blood pressure,CAIMT and Hcy levels in patients with H-type hyperten-sion who were treated with combined drugs intervention treatment(felodipine,captopril,folic acid and vitamin B),to investigate the clinical efficiency of combined drug intervention on patients with H-type hypertension. Methods Eighty-six patients with H-type hypertension were given the combined drugs intervention treatment(felodipine,captopril,folic acid and vitamin B)for 8 weeks,and thus the changes of blood pressure,CAIMT and serum Hcy levels before and after intervention were comparatively an-alyzed. Results Before intervention,SBP,DBP,CAIMT and serum Hcy levels of observation group,[(168. 9 ± 10. 4)mm Hg (1 mm Hg = 0. 133 kPa),(92. 5 ± 11. 3)mm Hg,(24. 7 ± 5. 3)μmol/ L,0. 98 ± 0. 19],were significantly higher than those of control group which were[(123. 5 ± 6. 6)mm Hg,(71. 8 ± 7. 9)mm Hg,(9. 8 ± 2. 7)μmol/ L,0. 57 ± 0. 14],P < 0. 01;and SBP,DBP,CAIMT and serum Hcy levels of observation group after intervention[(130. 2 ± 8. 9)mm Hg,(78. 7 ± 8. 6)mm Hg, (10. 9 ± 4. 2)μmol/ L,0. 76 ± 0. 13]were significantly lower than those before intervention(P < 0. 01). The total effictive rate of treatment was 94. 2%(81 / 86). Conclusion The combined drugs intervention(felodipine,captopril,folic acid and vitamin B) in the treatment of patients with H-type hypertension can significantly and effectively improve the blood pressure,carotid artery atherosclerosis and Hcy levels.