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目的研究接骨草水提物及醇提物的抗炎、镇痛作用。方法采用最大给药量评价接骨草两种提取物的急性毒性;采用二甲苯致小鼠耳廓肿胀法、醋酸致小鼠扭体法、热板致小鼠足痛法研究两种提取物的抗炎镇痛作用。结果接骨草的两种提取物均能明显抑制二甲苯致小鼠耳廓肿胀;明显对抗醋酸致小鼠扭体次数;明显延长热板法试验中小鼠的舔后足时间。结论给小鼠灌服接骨草水提物及醇提物未见明显毒性,两种提取物均具较好的抗炎、镇痛作用。
OBJECTIVE To study the anti-inflammatory and analgesic effects of water extract and alcohol extract of Salvia miltiorrhiza. Methods The maximum dose of the extract was used to evaluate the acute toxicity of two extracts of Jiegao Cao. The auricle swelling induced by xylene, the writhing induced by acetic acid and the foot pain induced by hot plate were used to study the effects of two extracts Anti-inflammatory analgesic effect. Results Both of the extracts of Jiemucao could obviously inhibit the auricle swelling induced by xylene in mice. It obviously antagonized the number of writhing induced by acetic acid in mice and prolonged the licking time of mice in hot-plate test. Conclusions There is no obvious toxicity to the mice by taking the extract of Salvia miltiorrhiza and its alcohol extract. Both extracts have good anti-inflammatory and analgesic effects.