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目的 观察心肌肌钙蛋白Ⅰ (cTnⅠ )诊断急性心肌梗死 (AMI)的敏感性和特异性。方法 AMI病人75例,对照组 54例。AMI病人于发病后 2~6小时, 6~12小时、12~24小时、1~3天、3~7天、7~10天采血,系列测定cTnⅠ和激酸激酶同功酶MB(CK MB)。对照组至少测定 1次cTnⅠ,CK -MB浓度,结果进行比较。结果 (1)AMI发病后 2~12小时,cTnⅠ的敏感性与CK MB对比无明显差异,但AMI发病后 12 ~24小时至 7 ~10天,cTnⅠ敏感性高于CK-MB。(2)血清cTnⅠ、CK- MB诊断AMI的特异性分别为 97 96%和 88 89%。结论 血清cTnⅠ是诊断AMI高度敏感、高度特异的指标;尤其AMI晚期,其阳性率远高于CK -MB,表明cTnⅠ诊断AMI的时间窗较CK MB宽。
Objective To observe the sensitivity and specificity of cardiac troponin Ⅰ (cTn Ⅰ) in the diagnosis of acute myocardial infarction (AMI). Methods AMI patients 75 cases, control group 54 cases. AMI patients were collected at 2 to 6 hours, 6 to 12 hours, 12 to 24 hours, 1 to 3 days, 3 to 7 days, and 7 to 10 days after the onset of disease. Serum cTnI and kininase MB ). The control group was measured at least once cTn Ⅰ, CK-MB concentration, the results were compared. Results (1) The sensitivity of cTnI was no significant difference between 2 and 12 hours after onset of AMI. However, the sensitivity of cTnI was higher than that of CK-MB after 12 to 24 hours and 7 to 10 days after onset of AMI. (2) The specificity of serum cTn I and CK-MB in diagnosing AMI was 97 96% and 88 89% respectively. Conclusions Serum cTnI is a highly sensitive and highly specific indicator for the diagnosis of AMI. Especially in the late stage of AMI, the positive rate of cTnI is much higher than that of CK-MB, indicating that the time window of cTnI in diagnosing AMI is wider than CKMB.