早在十九世纪就有学者在狗、鼠和猫胃中发现螺旋样的细菌［１，２］，本世纪早期也有零星报道在消化性溃疡患者胃内发现螺旋样的细菌［３］。对于这些细菌是否是人类胃肠道疾病的致病因子存在很大争论。当时大部分学者认为在胃粘膜组织中观察到的细菌可能是从口腔或咽喉等... As early as the 19th century, some scholars found helminth-like bacteria in the stomach of dogs, rats and cats [1,2]. Sporadic reports of spirochete-like bacteria were found in the stomach of patients with peptic ulcer in the early part of this century [3]. There is much debate about whether these bacteria are causative agents of human gastrointestinal diseases. Most scholars at the time believed that the bacteria observed in gastric mucosa might be from the mouth or throat ...