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目的回顾性调查男性不育症患者染色体异常发生情况,为不育症诊治的临床路径提供科学依据。方法对2007年-2009年在我所就诊的1060例男性不育症患者,进行外周血染色体核型分析。结果 1060例中有89例染色体异常,异常发生率为8.40%。其中染色体数目异常有20例,占异常染色体的比例22.47%;结构异常13例,占异常染色体的比例14.61%;染色体多态性有55例,占异常染色体的比例61.80%,女性性反转1例。性染色体异常68例,占异常染色体的比例为76.40%;常染色体20例,占异常染色体的比例为22.47%。结论染色体异常在男性不育症患者中有一定的发生率,对此类患者进行染色体核型分析是十分必要的。
Objective To retrospectively investigate the incidence of chromosomal abnormalities in male infertility and provide a scientific basis for clinical diagnosis and treatment of infertility. Methods Peripheral blood chromosome karyotype analysis was performed on 1060 male infertility patients from 2007 to 2009 in our hospital. Results In 1060 cases, 89 cases of chromosomal abnormalities, the abnormal incidence was 8.40%. There were 20 abnormal chromosomes, accounting for 22.47% of the abnormal chromosomes; 13 abnormal structures, accounting for 14.61% of the abnormal chromosomes; 55 chromosomal aberrations, accounting for 61.80% of the abnormal chromosomes and 1 example. 68 cases of sex chromosome abnormalities, accounting for 76.40% of the anomalous chromosomes; autosomal 20 cases, accounting for 22.47% of the abnormal chromosomes. Conclusion Chromosomal abnormalities in male infertility patients have a certain incidence, for such patients for karyotype analysis is necessary.