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Glaucomatous optic neuropathy is characterized byprogressive loss of retinal ganglion cells associatedwith visual functional deficits. As the ganglion cells die inglaucoma, there is a progressive thinning of the nervefibre layer (NFL). The underlying pathophysiologicalmechanisms, however, remain unclear. Manymechanisms are involved in the initiation and process ofirreversible ganglionic cell death in glaucoma. Theseinclude reduced axoplasmic transport, accumulation oftoxic levels of neurotransmitter,increased nitric oxide5and endothelin syntheses,and remodelling of theextracellular matrix, among others.
Glaucomatous optic neuropathy is characterized by progressive loss of retinal ganglion cells associated with visual functional deficits. As the ganglion cells die inglaucoma, there is a progressive thinning of the nerve fibre layer (NFL). The underlying pathophysiological mechanisms, however, remain unclear. Manymechanisms are involved in the initiation and process of irreversible ganglionic cell death in glaucoma. Theseinclude reduced axoplasmic transport, accumulation oftoxic levels of neurotransmitter, increased nitric oxide5and endothelin syntheses, and remodeling of theextracellular matrix, among others.