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Culling等(1976)报道正常结肠粘膜用磷钨酸苏木素/氢氧化钾/过碘酸Schiff技术染色时呈红色而结肠癌则染蓝色和紫色.这提示结肠癌的粘蛋白特性与正常不同.本文将Culling染色技术应用于家族性多发性结肠息肉病(FPC)患者的结肠粘膜,以了解其扁平粘膜内是否存在粘蛋白异常.对62例FPC外科切除标本的扁平粘膜作了研究.另收集41例结肠癌、39例腺癌、11例绒毛状或管状绒毛状腺瘤、74例癌肿附近的正常粘膜以及67例经钡灌肠或纤维结肠镜检查证实无结肠病变的正常人作为对照.与Culling的结果一致,所有癌肿均被染成蓝色,而且几乎所有(81.8%)绒毛状或管状绒毛状腺瘤的染色与癌肿相似.但正常粘膜也有38.8%染成紫色或蓝色.无腺瘤FPC患者的扁平
Culling et al. (1976) reported that normal colon mucosa stained red with phosphotungstic acid hematoxylin/potassium hydroxide/periodic acid Schiff technology and colon and colon cancer stained blue and purple. This suggests that the mucin characteristics of colon cancer are different from normal. In this paper, Culling staining technique was applied to the colonic mucosa of patients with familial multiple colon polyposis (FPC) to find out if there were mucin abnormalities in the flat mucosa. The flat mucosa of 62 FPC surgical specimens was studied. 41 cases of colon cancer, 39 cases of adenocarcinoma, 11 cases of villous or tubular villous adenoma, 74 cases of normal mucosa near the cancer, and 67 cases of normal colon without colon lesions confirmed by barium enema or colonoscopy were used as controls. Consistent with the results of Culling, all cancerous lesions were stained blue, and almost all (81.8%) villous or tubular villous adenomas stained similarly to cancerous lesions, but 38.8% of normal mucosa also stained purple or blue. . Non-adenomas FPC patients flat