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目的研究内皮素-1(ET-1)在乳腺癌组织中的表达及临床意义。方法采用免疫组织化学法检测乳腺癌组织、乳腺纤维腺瘤及癌旁正常组织中ET-1的表达,结合乳腺癌临床分期进行统计学分析。结果 ET-l在乳腺癌组织、乳腺纤维腺瘤及癌旁正常组织中的阳性表达相比,差异有统计学意义(P<0.05);ET-l在乳腺癌组织中阳性表达最高,在癌旁正常组织中阳性表达最低。ET-1在乳腺癌各临床分期标本中的表达均差异有统计学意义(P<0.05),分期越晚,表达越高。结论 ET-1在乳腺癌中呈高表达,在乳腺癌的发生、发展中可能具有重要作用。
Objective To study the expression and clinical significance of endothelin-1 (ET-1) in breast cancer. Methods Immunohistochemistry was used to detect the expression of ET-1 in breast cancer, breast fibroadenoma and adjacent normal tissue. Statistical analysis was made on the clinical stage of breast cancer. Results The positive expression of ET-1 in breast cancer, breast fibroadenoma and adjacent normal tissue was significantly different (P <0.05). The positive expression of ET-1 in breast cancer was the highest, Next to normal tissue in the lowest positive expression. The expression of ET-1 in breast cancer staging specimens was significantly different (P <0.05), the later the stage, the higher the expression. Conclusion ET-1 is highly expressed in breast cancer and may play an important role in the development of breast cancer.