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目的观察加味香砂六君子汤联合胃复安治疗晚期直肠癌化疗后消化道不良反应的临床疗效。方法将60例晚期直肠癌患者随机分为治疗组和对照组,每组各30例,两组均于化疗前30 min给予胃复安20mg肌肉注射,治疗组加服加味香砂六君子汤,化疗第1天开始服用,每日早晚各服用1次,至化疗结束后持续服用7 d后停药。观察两组的疗效、卡氏评分。结果两组有效率比较,治疗组总有效率为93.33%,对照组总有效率为60.00%,两组比较差异有统计学意义(P<0.05);两组卡氏评分比较,治疗组提高稳定率为90%,对照组提高稳定率为63.33%,两组比较差异有统计学意义(P<0.05)。结论加味香砂六君子汤联合胃复安能明显减轻直肠癌患者化疗后所致消化道不良反应。
Objective To observe the clinical effects of Jiaxiang Xiangsha Liujunzi Decoction combined with Weifu An in treating gastrointestinal adverse reactions after chemotherapy for advanced rectal cancer. Methods Sixty patients with advanced rectal cancer were randomly divided into treatment group and control group, with 30 cases in each group. Both groups were given intragastric injection of metoclopramide 20mg 30 minutes before chemotherapy. The treatment group received Modified Xiangsha Liujunzi Decoction, The first day of chemotherapy began to take daily morning and evening take 1, until the end of chemotherapy after taking 7 days after discontinuation. The curative effect and Karnofsky score of the two groups were observed. Results The total effective rate was 93.33% in the treatment group and 60.00% in the control group, with significant difference between the two groups (P <0.05). Compared with the two groups, the treatment group improved The rate of 90% in the control group was 63.33%, the difference between the two groups was statistically significant (P <0.05). Conclusion Modified Xiangsha Liujunzi Decoction combined with metocaura can significantly reduce the gastrointestinal adverse reactions in patients with rectal cancer after chemotherapy.