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目的:比较过膜前、过膜后的安神补脑液在改善小鼠记忆障碍和方向辨别障碍方面的不同作用效果。方法:利用乙醇致小鼠记忆再现障碍模型,通过跳台法记录小鼠错误次数,比较过膜后各样品对记忆功能的改善作用;利用腹腔注射戊巴比妥钠致小鼠方向辨别障碍模型,通过水迷宫实验,观察各样品的对小鼠的益智作用。结果:过膜前高剂量组和过膜后高、低剂量组的安神补脑液能够改善乙醇致小鼠记忆再现障碍;过膜前、过膜后的安神补脑液都能显著改善小鼠的方向辨别障碍,尤其是过膜后效果更佳。结论:过膜后的安神补脑液保留了过膜前的记忆改善作用,并提高了其在方向辨别方面的保护作用。
OBJECTIVE: To compare the different effects of soothempatresin on brain membrane before and after membrane in improving memory impairment and disorientation in mice. Methods: The mice model of memory impairment was induced by ethanol. The number of mouse errors was recorded by the jump-table method. The improvement of memory function of each sample was compared. After intraperitoneal injection of pentobarbital sodium, Through the water maze test, the effects of each sample on mice were observed. RESULTS: Anshen Bunao Ye, a high-dose pre-membrane group and a high-dose and low-dose pre-membrane group, could improve the memory impairment of mice induced by ethanol. Before and after membrane administration, Anshen Bunao Solution could significantly improve the mice The direction of identification of obstacles, especially after the membrane effect is better. CONCLUSIONS: Subconjunctival buprenorphin after transmembrane preservation of premembrane memory improves the memory function and enhances its protective effect in direction discrimination.