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为深入探讨失重对胃肠内分泌功能的影响，用免疫组织化学ＡＢＣ染色法结合图象分析技术，研究了悬吊模拟失重大鼠胃窦部胃泌素（Ｇａｓ）、生长抑素（ＳＳ）、羟色胺（５－ＨＴ）和嗜铬颗粒素Ａ（ＣｇＡ）免疫反应（－ＩＲ）细胞的密度和灰度变化。结果显示，悬吊大鼠胃窦部Ｇａｓ－ＩＲ细胞和５－ＨＴ－ＩＲ细胞的密度与灰度均较对照鼠增加，而ＳＳ－ＩＲ细胞和ＣｇＡ－ＩＲ细胞的密度与灰度均较对照鼠减低。由于ＳＳ与Ｇａｓ和５－ＨＴ在功能上具有拮抗作用，因而表明，模拟失重状态下，胃窦部内分泌功能稳态可能有变化。
In order to further investigate the effect of weightlessness on the gastrointestinal endocrine function, immunohistochemical ABC staining and image analysis techniques were used to study the effects of gastrin, somatostatin (SS) Changes in density and grayscale of serotonin (5-HT) and chromaffinogranin A (CgA) immunoreactive (-IR) cells. The results showed that the density and gray scale of Gas-IR cells and 5-HT-IR cells in the gastric antrum of the suspension rats were increased compared with the control rats, while the density and gray scale of SS-IR cells and CgA-IR cells were higher than that of the control Reduce the mouse. Due to the functional antagonism of SS and Gas and 5-HT, it is suggested that the steady state of endocrine function of gastric antrum may change under simulated weightlessness.