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研究利用免疫组化方法，观察乳腺癌及良性病变是否有Bcl－2表达；Bcl－2表达及丧失与激素受体的相关性；Bcl－2表达与肿瘤分级的关系等。结果发现Bcl－2表达与ER、PR、肿瘤组织分级显著相关，Bcl－2表达阳性的乳腺癌多伴有ER＋（75％）、PR＋（70％），而Bcl－2阴性者ER、PR表达也少。因此乳腺癌中Bcl－2阴性表达与预后较差的分子标志呈正相关，即ER、PR阴性率高，组织分级高。我们的发现支持了乳腺癌Bcl－2表达受激素调节的假说。
To study the use of immunohistochemical methods to observe whether there is Bcl-2 expression in breast cancer and benign lesions; Bcl-2 expression and loss and hormone receptor correlation; Bcl-2 expression and tumor grade relationship. The results showed that Bcl-2 expression was significantly correlated with ER, PR, and tumor grade. Bcl-2 positive breast cancer was often associated with ER+ (75%), PR+ (70%), and Bcl-2 negative ER and PR expression. Also less. Therefore, the negative expression of Bcl-2 in breast cancer is positively correlated with the poor prognosis of the molecular markers, ie, the negative rate of ER and PR is high and the tissue grading is high. Our findings support the hypothesis that Bcl-2 expression is regulated by hormones in breast cancer.