Oct4是一种POU转录因子 ,属于Ⅴ类POU蛋白 ,在小鼠全能胚胎干细胞和生殖系干细胞表达。在早期鼠胚中 ,只有在ICM变成滋养层阶段 ,Oct4为维持其全能表型而发挥作用。Oct4表达可能是由位置效应引起的 ,还与特异调节Oct4活性的元件 ,如近端、远端增强子元件有关。Oct4对转录的调节分为抑制转录和转录激活两种。Oct4的激活有 3种模式 :远端依赖性共激活 ,构象依赖性共激活 ,Oct4聚合体依赖性共激活 Oct4 is a POU transcription factor belonging to class V POU protein that is expressed in mouse totipotent and germline stem cells. In early mouse embryos, Oct4 plays a role in maintaining its totipotent phenotype only when ICM becomes a trophoblast. Oct4 expression may be caused by the site effect and also with elements that specifically regulate Oct4 activity, such as proximal and distal enhancer elements. Oct4 regulation of transcription into inhibition of transcription and transcriptional activation of two. There are three modes of Oct4 activation: Distal-dependent co-activation, Conformation-dependent co-activation, Oct4-dependent co-activation