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目的探讨生殖免疫抗体对女性生育能力的影响。方法收集2013年8月至2014年7月在四川省妇幼保健院生殖医学中心就诊的1 428例女性不孕症患者资料,采用酶联免疫吸附(ELISA)方法进行生殖免疫抗体检测,分析生殖免疫抗体对女性生育能力的影响。结果有36.27%不孕症女性检测出抗体阳性,其中抗精子抗体(As Ab)、抗卵巢抗体(AOVAb)、抗子宫内膜抗体(AEMAb)、抗h CG抗体(Ah CGAb)、抗心心磷脂抗体(ACA-Ig G)阳性率分别为10.15%、20.66%、7.35%、6.02%、9.66%;继发不孕和原发不孕生殖免疫抗体均以单个抗体阳性为主,分别占72.39%和71.95%,继发不孕Ah CGAb、As Ab、AEMAb阳性率(7.30%、11.95%、8.90%)高于原发不孕(4.59%、8.15%、5.63%)(P<0.05),输卵管阻塞者AOVAb、AEMAb、ACA-Ig G阳性率(34.94%、9.94%、9.09%)高于输卵管通畅者(11.28%、2.05%、2.56%)(P<0.05)。结论生殖免疫抗体是女性不孕症的重要影响因素,与既往妊娠史和输卵管阻塞有关,应加强生殖健康教育,减少非意愿妊娠人工流产和生殖道感染,降低罹患不孕症的风险。
Objective To investigate the impact of reproductive immune antibody on female fertility. Methods A total of 1 428 female infertility patients who were referred to the Reproductive Medicine Center of MCH from August 2013 to July 2014 in our hospital were collected. The reproductive immunity antibody was detected by enzyme-linked immunosorbent assay (ELISA) Influence of Antibody on Female Fertility. RESULTS: 36.27% of infertile women tested positive for antibodies, including As Ab, AOVAb, AEMAb, Ah CGAb, anti-cardiolipin The positive rates of ACA-Ig G were 10.15%, 20.66%, 7.35%, 6.02% and 9.66% respectively. The positive rates of single antibody in secondary infertility and primary infertility were 72.39% And 71.95% respectively. The positive rates of Ah CGAb, As Ab and AEMAb in secondary infertility (7.30%, 11.95%, 8.90%) were higher than those in primary infertility (4.59%, 8.15%, 5.63% The positive rates of AOVAb, AEMAb and ACA-Ig G in obstructive cases were 34.94%, 9.94% and 9.09%, respectively, which were significantly higher than those in patients with tubal patency (11.28%, 2.05%, 2.56%) (P <0.05). Conclusion Reproductive immunity antibody is an important influencing factor of infertility in women. It is related to previous pregnancy history and tubal obstruction. Reproductive health education should be strengthened to reduce unwanted pregnancy induced abortion and reproductive tract infections and reduce the risk of infertility.