洋地黄的中毒反应多归咎于对心肌的直接作用,其它如噁心、呕吐、某些心律失常和视觉障碍可能起因于中枢神经。中毒死亡病人中6%出现视觉障碍,急性中毒达11～20%。本文采用Farnsworth’s Munsell100-Hue试验法,检查服用β-乙酰或β-甲基狄戈辛后病人的色视缺陷。51例住院病人,一组用β-甲基或β-乙酰狄戈辛治疗心衰患者持续4周以上,另一组为对照,在研究前4周不接受强心配糖体。凡有视觉疾病或所用药物已知可干扰狄戈辛的药物代谢动力学或药效学或对放射免疫测定狄戈辛有交叉反应者,以及糖尿病及高血压患者均应剔除。病人平均年龄60±11,血清钾浓度为4.25± The toxic effects of digitalis are mostly attributed to the direct effects on the myocardium. Others such as nausea, vomiting, certain arrhythmias, and visual disturbances may be caused by the central nervous system. 6% of patients died of visual impairment, acute poisoning reached 11 to 20%. In this paper, Farnsworth’s Munsell100-Hue test was used to examine the color vision defects of patients after taking β-acetyl or β-methyl Dicosin. Fifty-one inpatients, one group of patients with heart failure treated with beta-methyl or beta-acetyl digoxin for more than 4 weeks and the other as a control, did not receive cardiotoxicity with glucocorticoid 4 weeks prior to the study. Anyone who has a visual condition or which medication is known to interfere with the pharmacokinetics or pharmacodynamics of Digoxigen or who cross-react with radioimmunoassay, and with both diabetes and hypertension, should be excluded. The average patient age was 60 ± 11 and the serum potassium concentration was 4.25 ±