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【目的】了解婴幼儿乳房早发育的特点及其发展为中枢性性早熟的比率。【方法】对2007年7月—2010年8月在本院进行体检发现乳房结节的162名1月~3.4岁的婴幼儿进行定期体检、随访,年龄>2岁、乳房结节2.5 cm及乳房结节退而复现的患儿,均进行腹部、乳房B超,性激素、骨龄等相关检查。据病情需要进行GnRH激发试验、头颅MRI检查。【结果】乳房结节最常见出现年龄在5~8月龄,到2岁半消失者达96.91%,出现乳房结节患儿的喂养方式中纯母乳喂养>混合喂养>人工喂养。不同喂养方式在患儿乳房结节大小、乳房结节退而复现及乳房结节单侧或双侧出现方面差异均无统计学意义。卵巢、性激素及骨龄异常者占乳房早发育的2.47%,GnRH激发试验均阴性,中枢性性早熟的发生率为0。【结论】婴幼儿乳房早发育大多是一种良性情况,但应注意观察随诊,以便早期发现中枢性性早熟的征象,及时干预治疗。
【Objective】 To understand the characteristics of infant breast early development and the development of central precocious puberty. 【Methods】 From July 2007 to August 2010, 162 infants and young children aged from 1 month to 3.4 years old with breast nodules who had physical examinations in our hospital were examined regularly. The patients were followed up for more than 2 years with 2.5 cm of breast nodules Breast nodules reappear in children, are abdomen, breast ultrasound B, sex hormones, bone age and other related tests. According to the condition need to GnRH provocation test, head MRI examination. 【Results】 The most common occurrence of breast nodules was from 5 to 8 months of age, reaching 96.91% of those disappeared after 2 years and half. Breast nodules were fed exclusively in breastfeeding, mixed feeding and artificial feeding. Different feeding methods showed no significant difference in breast nodule size, recurrence of breast nodules and unilateral or bilateral breast nodules. Ovarian, sex hormone and abnormal bone age accounted for 2.47% of early breast development, GnRH provocation test were negative, the incidence of central precocious puberty was 0. 【Conclusion】 Infant breast early development is mostly a benign condition, but follow-up should be observed, so early signs of central precocious puberty can be found and timely intervention can be achieved.